diff --git a/src/portable/nordic/nrf5x/dcd_nrf5x.c b/src/portable/nordic/nrf5x/dcd_nrf5x.c
index e70565a02..024ea0d90 100644
--- a/src/portable/nordic/nrf5x/dcd_nrf5x.c
+++ b/src/portable/nordic/nrf5x/dcd_nrf5x.c
@@ -463,11 +463,17 @@ bool dcd_edpt_xfer (uint8_t rhport, uint8_t ep_addr, uint8_t * buffer, uint16_t
 
   xfer_td_t* xfer = get_td(epnum, dir);
 
-  dcd_int_disable(rhport);
+  if (!is_in_isr()) {
+    osal_mutex_lock(dcd_mutex, OSAL_TIMEOUT_WAIT_FOREVER);
+    dcd_int_disable(rhport);
+  }
   xfer->buffer     = buffer;
   xfer->total_len  = total_bytes;
   xfer->actual_len = 0;
-  dcd_int_enable(rhport);
+  if (!is_in_isr()) {
+    dcd_int_enable(rhport);
+    osal_mutex_unlock(dcd_mutex);
+  }
 
   // Control endpoint with zero-length packet and opposite direction to 1st request byte --> status stage
   bool const control_status = (epnum == 0 && total_bytes == 0 && dir != tu_edpt_dir(NRF_USBD->BMREQUESTTYPE));